In a nutshell
This research checked out exenatide (Byetta) for sufferers with kind 2 diabetes (T2D) and kidney injury. It discovered that exenatide could scale back kidney injury in comparison with different diabetes therapies.
T2D is a dysfunction by which the physique doesn’t reply effectively to the hormone insulin. This causes excessive ranges of glucose (sugar) within the blood. Diabetes can result in issues together with kidney injury.
Kidney perform might be measured by estimated glomerular filtration charge (eGFR), or how shortly the kidneys can filter blood. When the kidneys are broken, proteins together with albumin can go from the blood into the urine. That is measured by the urine albumin to creatinine ratio (uACR).
Exenatide is a diabetes remedy. Exenatide mimics a hormone the intestine launched after consuming and will increase the quantity of insulin the physique releases. Previous research have discovered that exenatide improves blood glucose management and will help scale back physique weight. Nevertheless, it’s unclear whether or not exenatide reduces kidney injury in sufferers with T2D.
Strategies & findings
This evaluation included six part III research of sufferers with T2D and albumin within the urine (uACR over 30 mg/g). 674 sufferers began the research, and 468 sufferers remained by means of week 26 or 28 of the research. 194 of those sufferers took exenatide, and 274 used a unique remedy. The research used both insulin or oral diabetes remedy as a comparability remedy.
Albumin within the urine decreased extra within the exenatide group in comparison with different therapies (uACR discount of 55.5% vs. 39.7%). Research that used insulin as a comparability remedy had related outcomes to these which used oral medicines. Sufferers with early kidney illness (uACR between 30 and 300 mg/g) had extra profit from exenatide than sufferers with extra pronounced kidney illness (uACR over 300 mg/g).
Glycated hemoglobin (HbA1c) is an estimate of glucose management over the earlier two to a few months. Glucose management improved considerably extra for the exenatide group (HbA1c discount of 1.four% vs. 1.zero%). Sufferers taking exenatide misplaced a mean of two.three kg (5.1 lbs), whereas sufferers taking comparability therapies gained a mean of zero.5 kg (1.1 lb).
Each teams had a low charge of significant unwanted side effects. Sufferers taking exenatide have been extra more likely to expertise gastrointestinal unwanted side effects (34.9% vs. 17.9%).
The underside line
This research discovered that exenatide could enhance kidney perform in sufferers with diabetes.
The tremendous print
The research used on this evaluation weren’t designed to check for the impact of exenatide on kidney illness. These outcomes should be confirmed with extra research. This research was funded by AstraZeneca, the producer of Byetta.
Printed By :
Diabetes, Weight problems and Metabolism
Apr 23, 2020
Unique Title :
Exenatide as soon as weekly decreases urinary albumin excretion in sufferers with kind 2 diabetes and elevated albuminuria: pooled evaluation of randomized energetic managed scientific trials.
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